Nmblr Convince Step 1: Disease Burden and Unmet Need

Purpose of this step

To define the problem your asset must solve. Show the scale and impact of the disease and where current options fall short. By making the unmet need explicit, you set the value drivers and create a clear anchor for all subsequent messages.

Define the problem you solve (disease burden & unmet need):

• Core message: Describe, in one sentence, how the current standard of care leaves a meaningful gap that harms patients and strains systems.
• Supporting messages: These are required to ensure the core message is credible. May include epidemiology and trends; severity/progression; QoL/PROs; care-pathway friction; current cost and resource strain; disparities/inequities where relevant. Use any patient journey work to inform these.